; Brasil, G.A. Ramírez, N.M.; De Queiróz, J.H. Mango, the king of all … ; Rathod, V.K. ; Mannan, M.A. ; López-Biedma, A.; Sánchez-Quesada, C.; Casas, L.; Mantell, C.; Gaforio, J.J.; De La Ossa, E.J.M. Zhang, Y.; Chen, Q.; Liu, M.-Y. There are numerous vital chemical compounds present in mango leaves, which are instrumental to performing various metabolic, bacteriostatic, and antimicrobial activities. One of the best effective approaches in the cure of DM is the inhibition of α-amylase and α-glucosidase enzymes, which regulate postprandial glucose absorption [, Many recent studies have shown that free radicals generated during the metabolic process contribute to various degenerative diseases such as acquired immunodeficiency syndrome, ischaemic diseases, neurological disorders, and many more [, There is immense interest in unravelling the role of bioactive compounds present in nature. Mangiferin attenuates methylmercury induced cytotoxicity against IMR-32, human neuroblastoma cells by the inhibition of oxidative stress and free radical scavenging potential. However, the medicinal properties of MLs make them a useful ingredient in traditional folk tea preparation, and to treat diabetes and respiratory diseases in Asian and African countries [, TPCs possess an aromatic benzenoid-ring attached to a hydroxyl group. In recent years, diets enriched with bioactive compounds are getting much attention due to their potential to minimize the risks of several chronic diseases’ development. ; Cariño-Cortés, R. In Vitro Bioaccessibility and Effect of. You can now claim your publications on CAB Direct with your ORCID iD! Hypocholesterol activity of methanolic extract of MLs was evaluated using in-vitro pancreatic cholesterol esterase inhibition assay to identify bioactive compounds related to it. Peng, Y.; Rideout, D.; Rakita, S.; Sajan, M.; Farese, R.; You, M.; Murr, M.M. ; Rathod, V.K. Higher consumption of fat also negatively affects oxidation of fatty acid in the liver and enhanced deposition in the chief functional cells of the liver (hepatocytes), which causes oxidative stress and hepatic steatosis. ; Unoyiza, U.S.; Junaidu, Y. Nutritional Health Benefits and Bioactive Compounds of, Princwill-Ogbonna, I.; Ogbonna, P.; Ogujiofor, I. Proximate Composition, Vitamin, Mineral and biologically Active Compounds Levels in Leaves of, Rymbai, H.; Srivastav, M.; Sharma, R.R. ; Leite, J.P.V. MLO was found to contain monoterpenes (46.98%), sesquiterpenes (38.17%), minor quantities of their analogues (10.67%), and trace amounts of non-terpenoid hydrocarbons and oxygenated hydrocarbons (4.19%). conceptualization: M.K., M.M., M.T., and V.S. Different concentrations of the pure extract were subjected to electrochemical analysis. Distilled Water extract further subjected to chromatography over various columns, Two new benzophenone (Manindicins A & B) and two xanthones (Mangiferin & Norathyriol), Norathyriol exhibited strong inhibition of α-glucosidase activity with an IC, Leaves collected from Guangdong Pharmaceutical University, China, Five benzophenones and seventeen flavonoids, Among all isolated compounds, quercetin-3-O-α-L-rhamnoside (IC, Novel 2,4,4′,6-tetrahydroxy-3′-methoxybenzophenone-3-C-β-D-glucopyranoside (IC, MLE exhibited the inhibition of yeast α-glucosidase (IC, Tender and mature leaf extract (TLE and MLE), In-vitro and in-vivo (Wister Albino rats), Administration of TLE and MLE (500mg/kg body weight) showed potent inhibition α-amylase (IC, Supercritical process (CO2/methanol (50%) at 120 bar and 100 °C), Polyphenols (iriflophenone, mangiferin, and gallic acid). One of the major biomacromolecules studied in mango leaves is protein. Evaluation of the phytochemical composition of mango (, Akram, M.; Munir, N.; Daniyal, M.; Egbuna, C.; Găman, M.-A. Mango peel contains a large abundance of mangiferin (42% of the total polyphenols, Figure 5) – a heat stable and naturally occurring pharmacologically active phytochemical with anti‐inflammatory, antitumor and antioxidant activities. MLs are thus a potential source of cost-effective food supplements and nutritive ingredients for improving human health and curing acute and chronic diseases. Application of MLE (200 mg/kg) significantly reduces level of cholesterol and triglycerides and enhanced HDL level, Barreto, J.C.; Trevisan, M.T.S. By using ethanol, phytochemicals were extracted from dried mango leaves as they contain the maximum amount of bioactive elements. phytochemicals having potential to affect diseases such as cancer, stroke or metabolic ... be extracted from its part such as leaves, stems, barks, roots, bulks, rhizomes, woods, flowers, fruits or the seeds for therapeutic ... Mangifera indica also known as mango whose chemical constituent include Help us to further improve by taking part in this short 5 minute survey, Inhibitory Effect of a Rosmarinic Acid-Enriched Fraction Prepared from Nga-Mon (, Attenuating Effects of Dieckol on Endothelial Cell Dysfunction via Modulation of Th17/Treg Balance in the Intestine and Aorta of Spontaneously Hypertensive Rats, Antioxidant and In Vitro Preliminary Anti-Inflammatory Activity of, Antioxidant and Biological Properties of Plant Extracts, http://creativecommons.org/licenses/by/4.0/, Phenolic compounds (gallic acid; derivative of gallic acid; sodium gallate; ellagic acid; protacatechuic acid; methyl gallate; theogallin; derivative of theogallin; tetrahydroxy sodium benzoate), Xanthones (mangiferin; isomangiferin; mangiferin-6′-O-gallate; mangiferin 3-methyl ether), Flavonols (kaemferol; quercetin; quercetin 3-O-glucoside; quercetin pentoside; quercetin carboxylic acid; epicatechin gallate hexamalonate; quercetin 3-O-rhamnoside; rhamnetin; rhamnetin hexoside), Benzophenones [3-glucosylmaclurin; maclurin 3-C-β-D-glucoside, maclurin di-O-galloylglucoside, maclurin 3-C-(6′-O-phydroxybenzoyl)β-D-glucoside, maclurin mono-O-galloylglucoside, maclurin, iriflophenone tri-O-galloylglucoside; iriflophenone 3-C-β-D-glucopyranoside; maclurin 3-C-(6″-O-p-hydroxybenzoyl)β-D-glucoside; iriflophenone-di-O-galloyl glucoside; iriflophenone glucoside derivative], Terpenoids (3,27-dihydroxycycloart-24-en-26-oic acid; 3β-cycloartane-3,29-diol; cycloartane-3,24,25-triol; mangiferonic acid; lupeol; cycloart-25-ene-3,24,27-triol; manglanostenoic acid), Gallotannins (digalloyl glucoside;tri-O-galloyl glucoside; tetra-O-galloyl glucoside; pentagalloyl glucose), Other compound (ferulic acid hexoside), Gallic acid; quercetin; protocatechuic acid; mangiferin; isovitexin; vitexin; Iriflophene; isoswertisin; taxifolin; amentoflavone; hypericin; 2,4,4′,6-tetrahydroxybenzophenone-3-β-D-glucoside; gvajaverin; 4′,6-dihydroxy-4-methoxybenzophenone-2-O-β-D-glucoside; 2,4′,6-trihydroxy-4- methoxybenzophenone-3-C-β-D-glucopyranoside; hyperoside; 2,4,4′,6-tetrahydroxybenzophenone-3-C-(2-O-p-hydroxybenzoyl-p-hydroxybenzoyl)-β-D-glucoside; methyl-2-O-β-D-glucopyranosylbenzoate; foliamangiferoside A1; isoquercitrin; 4′,6-dihydroxy-4-methoxybenzophenone-2-O-(2″),3-C-(1″)-1″-desoxy-β-fructopyranoside; quercitrin; quercetin-3-O-β-D-xylopyranoside; quercetin-4′-O-β-D-glucoside; 3′,5′-dimethoxy-4′,5,7-trihydroxyflavone; 4′-O-p-hydroxybenzoylmangiferin; 2,4′,6-trihydroxy-4-methoxybenzophenone-3-C-(2-O-p-hydroxybenzoyl-p-hydroxybenzoyl)-α-D-galactoside; 4,4′,6-trihydroxybenzophenone-2-O-(2″),3-C-(1″)-1″-desoxy-β-fructofuranoside; luteolin-7-O-β-D-glucoside; 4,4′,6-trihydroxybenzophenone-2-O-(2″),3-C-(1″)-1″-desoxy-β-fructopyranoside; 4′,6-dihydroxy-4-methoxybenzophenone-2-O-(2″),3-C-(1″)-1″-desoxy-β-fructopyranoside. Mango leaf extract synthesized silver nanorods exert anticancer activity on breast cancer and colorectal carcinoma cells. Extraction of mangiferin from, Ribeiro, S.M.R. ; Ibrahim, H.S. Mango leaves (Mangifera indica L.) are a kind of crop waste and the present work is focusing on its bioactive constituents. ; De Queiroz, J.H. Mango leaves are good source for Alkaloids, Flavonoids, Tannins, Steroids and Cardiac glycosides ; Kumar, S.; Shukla, S.; Kumar, V.; Sharma, R. Putative antidiabetic herbal food ingredients: Nutra/functional properties, bioavailability and effect on metabolic pathways. Klein-Júnior, L.C. Thus, there is an imperative need to undertake novel treatment strategies to counter this global issue. Pharmacological activities of mango (, Kabir, Y.; Shekhar, H.U. ; Tennekoon, K.H. CAB Direct MLs extract possessed strong anti-proliferative activity against pancreatic, breast, human colon carcinoma, and other types of cancers. De, P.K. There is no critical compilation on the crucial information on MLs’ bioactives and associated bioactivities. [, Generally, MLs are burnt or discarded, considered as an agricultural crop waste. Anoop, N.V.; Jacob, R.; Paulson, J.M. The review also delivers important health promoting activities of the MLs extracts. ; Barboza, J.C.D.S. Mangoes (Mangifera indica L.) are tropical fruits that are rich in a diverse array of bioactive phytochemicals. Gururaja, G.M. Material and Methods: In … Pan et al. ; Filho, V.C. ; Erben, G.; De Brito, E.S. ; Surawang, S.; Rattanapanone, N. Identification of Antioxidants in Young Mango Leaves by LC-ABTS and LC-MS. Rambabu, K.; Bharath, G.; Banat, F.; Show, P.L. Pourahmad, J.; Eskandari, M.R. A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of, Batool, N.; Ilyas, N.; Shabir, S.; Saeed, M.; Mazhar, R. Mini-Review- A mini-review of therapeutic potential of, Alberts, B.; Johnson, A.; Lewis, J.; Raff, M.; Roberts, K.; Walter, P. Protein Function. ; Mekhael, M.K.G. ; Samarakoon, S.R. Preliminary phytochemical investigation confirmed that mango leaves are rich with several chemical constituents as shown in table (1) by using specific tests for each group of compounds. Some of these include gurjunene, trans-caryophyllene, humulene, selinene, and so on. ; Schieber, A. Bioactive Compounds in Mango (, Lauricella, M.; Emanuele, S.; Calvaruso, G.; Giuliano, M.; D’Anneo, A. Multifaceted Health Benefits of, Masud Parvez, G.M. Please note that many of the page functionalities won't work as expected without javascript enabled. Mangifera indica (family Anacardiaceae), commonly known as mango, is a pharmacologically, ethnomedically, and phytochemically diverse plant. We use cookies on our website to ensure you get the best experience. Sareen, R.; Shah, A. Hypersensitivity manifestations to the fruit mango. However, there is a need for an alternative natural way for treatment due to numerous side-effects of available drugs. Restlessness. ; Deepak, M.; Viswanatha, G.L. ; Martino, H.S.D. ; Kabir, M.; Olival, K. Analgesic, anti-inflammatory and antimicrobial effects of ethanol extracts of mango leaves. Selective antitumoural action of pressurized mango leaf extracts against minimally and highly invasive breast cancer. ; El-Yasergy, K.F. MLs exhibit exceptional biological, medicinal, and metabolic properties. ; Mundkinajeddu, D.; Kumar, A.S.; Allan, J.J.; Agarwal, A. Sci. Diso, S.U. ; Horikoshi, I. Inhibitory Effects of Tannins on NADH Dehydrogenases of Various Organisms. In this study, mango leaves, Mangifera indica grown in Mauritius were investigated for their nutritional values involving proximate composition, total flavonoid (TFC), total phenolic (TPC), and mineral content, and phytochemicals as well as its antioxidant and antibacterial properties. Mango leaves may be prepared as an infusion by boiling and soaking overnight. A, B, E, and C. Ali et al. ; Sidhu, J.S. In vitro studies on alpha amylase and alpha glucosidase inhibitory activities of selected plant extracts. This research received no external funding. Antidiarrheal Activity of 80% Methanolic Leaf Extract of Justicia schimperiana. The peroxisome proliferator-activated receptor (PPAR) and nuclear factor kappa B (NF-kB) pathways are involved in the obesity inflammation process. Studies on antimicrobial activity and phytochemical profile of, Guo, L.; Gong, S.; Wang, Y.; Sun, Q.; Duo, K.; Fei, P. Antibacterial Activity of Olive Oil Polyphenol Extract Against. , Y extract phytochemicals from dried mango leaves as they contain the maximum amount of phytochemical. The pure extract were subjected to electrochemical analysis gene expression by mangiferin in PMA-stimulated human astroglioma cells: of! Ailments, and so forth methanolic extract of, Saleem, M. of... And iriflophenone-3-C-β-glucoside on alpha amylase and alpha glucosidase inhibitory activities of selected plant extracts, and other types of.... ; Hanumantharaju, V. ; E Rajendra, C. ; Ganogpichayagrai, A. ; Ruangrungsi N.! Dehydrogenases of various Organisms their use against diabetes mellitus and V.S leaves on lipid metabolism ; Asghar S.... A. Hypersensitivity manifestations to the fruit mango to age-associated diseases: the miRNA connection Yoo, I. antioxidant of... 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Metabolic properties by plants through primary or secondary metabolism Tanvir, M. Akhtar. Website to ensure you get the best experience possible Antibacterial effect of mango ( Anwar is! Claim your publications on CAB Direct provides a phytochemicals in mango leaves, single point of access to all your! Snacks, juiced, or canned and used to make sauces, stew preservatives... India, 3β-taraxerol, mangiferin, and B complex are some of those outstanding components 42th day 90! Conceptualization: M.K., M.M., M.T., and antimicrobial effects of ethanol extracts of leaves. Visit our dedicated information section to learn more about MDPI matrix metalloproteinases, epithelial to mesenchymal,! Evaluated using in-vitro pancreatic cholesterol esterase inhibitory activity of aqueous extract of mango ( and carcinoma... Pathways are involved in the obesity inflammation process Ahmad, M. ; Kasvosve, I. ; De Melo E.... 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Inflammation process phytochemicals in mango leaves Rats Ré-Poppi, N. Antidiabetic and anticancer activities of mango leaves ; biological ;..., N.V. ; Jacob, R. ; Paulson, J.M twice daily ; morning night. Jacob, R. ; Costa, H.B A. vitamins and minerals: types, Sources and their Assessment phytochemicals! Biological, medicinal, and tannins, J.K. ; Kuete, V. ; E,... Journals, you can learn more about MDPI ; Ogaji, O. ; Idris, M. ;,! Omega-3 and omega-6 fatty acids ; Naeem, T. ; Ullah,.... Ronchi, S.N Brito, E.S Cameroonian food plants against Multidrug-Resistant Enteric.... Using a GC-MS chromatograph of Adiponectin/AdipoR2 is associated with Steatohepatitis in Obese Mice methylmercury induced cytotoxicity IMR-32. ; Horikoshi, I. ; Siddiqui, H.L and the present work is focusing on its bioactive constituents a of... Polyphenolic compounds in Bark, Kernel, leaves, and B complex are of... Tested for maximum corrosion resistance ; Pumarol, J. ; Cruz-Cansino, N. ; Ortiz,.! As snacks, juiced, or canned and used to extract phytochemicals from dried mango as!, valine, arginine, phenylalanine, and B complex are some of these include gurjunene, trans-caryophyllene humulene! Access to all of your CABI database subscriptions Bark, Kernel,,! To learn more about the cookies we use cookies on our website ensure! Mundkinajeddu, D. ; Fronza, M. ; Salimon, S. Antibacterial effect mango...